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RESEARCH

The McCreedy Lab investigates the roles of early inflammation in tissue damage and wound healing following spinal cord injury. We are also developing new three-dimensional imaging strategies to characterize spinal cord neural circuits in the intact and injured spinal cord. With the knowledge gained from these studies, we aim to develop novel neuroprotective strategies to reduce inflammatory damage and improve long-term recovery for the spinal cord injured patient.

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INFLAMMATION AFTER SPINAL CORD INJURY

We employ genetic and pharmacological methods to study the accumulation and activation of early arriving immune cells, predominantly neutrophils. 


Image: Lightsheet image of neutrophils in the injured spinal cord.​

3D TISSUE CLEARING & LIGHTSHEET IMAGING
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Utilizing tissue clearing techniques and lightsheet microscopy, we can gain new insight into inflammation, tissue damage, and wound healing after spinal cord injury.


Image: 3D lightsheet image of spinal interneurons (pseudo-colored by depth). 

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